By Carl Eisdorfer PhD MD
Big apple 1982 Springer. eightvo, 436pp., index, unique gilt revealed hardcover. VG, tiny chip on entrance, no DJ.
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Extra info for Annual Review of Gerontology and Geriatrics, Volume 3, 1982: Clinical, Behavioral and Social Issues
Better interpretation of such studies will require genetic and pathophysiological delineation of clinical subclasses of these patients. , 1962; Pare and Mack, 1971). In their experience, patients who responded to one class of antidepressant tended not to respond to the other. Patients showed the same pattern of pharmacologic responsiveness during a subsequent episode of depression, which might have been precipitated by quite different life stresses. Also, relatives who had affective disorders shared the pattern of responsiveness or nonresponsiveness of the proband patient.
This pattern of polygenic control of individual differences in drug level or action is probably much more common than the single-gene pattern exemplified by atypical PsChE and slow acetylation and summarized in Table 2-1. others Not applicable (rare families) Not applicable 5-7% Debrisoquine, guanoxan, Side effects sparteine, phenacetin of each drug 1:2500 Suxamethonium 1:20,000 General anesthetics, suxamethonium Very rare Oral anticoagulants Very rare Oxidant drugs Based upon Motulsky (1972), Vesell (1973), Omenn and Motulsky (1978).
Ontogeny of B-lymphocyte function. V. Thymus cell involvement in the functional maturation of B-lymphocytes from fetal mice transferred into adult irradiated hosts. J. Exp. Med. 142:196. , and Singh, A. K. 1979. Age-related changes in human thymus. Clin. Exp. Immunol. 37:507. Singhal, S. , Roder, J. , and Duwe, A. K. 1978. Suppressor cells in immunosenescence. Fed. Proc. 37:1245. Smith, G. , and Walford, R. L. 1977. Influence of the main histocompatibility complex on ageing in mice. Nature 270:727.
Annual Review of Gerontology and Geriatrics, Volume 3, 1982: Clinical, Behavioral and Social Issues by Carl Eisdorfer PhD MD