By David A. Gewirtz, Shawn E. Holt, Steven Grant
This e-book offers perception into confirmed practices and study into apoptosis and senescence. the amount completely examines novel and rising ideas and learn within the fields of telephone loss of life pathways, senescence development arrest, medications and resistance, DNA harm reaction, and different themes that also carry mysteries for researchers. In overall, this quantity presents easy scientists and clinicians with a deeper and extra whole knowing of the mobile responses of malignancies that may be sure the effectiveness of therapy, either within the preliminary phases of the sickness in addition to in sickness recurrence.
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Extra info for Apoptosis, Senescence and Cancer (Cancer Drug Discovery and Development)
Lowe SW, Ruley HE, Jacks T, Housman DE. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 1993; 74:957–67. 266. Bunz F, Hwang PM, Torrance C, et al. Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J Clin Invest 1999; 104(3):263–9. 267. Merritt AJ, Allen TD, Potten CS, Hickman JA. Apoptosis in small intestinal epithelial from p53-null mice: evidence for a delayed, p53-independent G2/M-associated cell death after gamma-irradiation. Oncogene 1997; 14:2759–66.
Cell 1996; 86(1):147–57. 60. Kluck RM, Martin SJ, Hoffman BM, Zhou JS, Green DR, Newmeyer DD. Cytochrome C activation of CPP32-like proteolysis plays a critical role in a xenopus cell-free apoptotis system. EMBO J 1997; 16(15):4639–49. 22 Part I / Apoptosis and Alternative Modes of Cell Death 61. Hampton MB, Zhivotovsky B, Slater AF, Burgess DH, Orrenious S. Importance of the redox state of cytochrome C during caspase activation in cytosolic extracts. Biochem J 1998; 329:95–9. 62. Zamzami N, Kroemer G.
Although the phenomena had been described for almost a century, in 1972, Kerr, Wyllie, and Currie (1) first coined the term “apoptosis” to differentiate naturally occurring developmental cell death from the necrosis that results from acute tissue injury.
Apoptosis, Senescence and Cancer (Cancer Drug Discovery and Development) by David A. Gewirtz, Shawn E. Holt, Steven Grant