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By Cecelia M O'Connor; G E W Wolstenholme; International Union of Biological Sciences

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In phosphate buffer, at least one ionization constant (Laidler, 1958) must have a different value in the two enzyme-substrate complexes, since the pH optima are different. I n Tris buffer and in glycine buffer, the pH optima of both enzymes W. KALOW 46 are probably alike. However, the activity of the normal enzyme is greater than that of the atypical enzyme. As reported by Fraser (1956) and by Erdos and co-workers (1958), several alkaloids, amino acids and quaternary ammonium compounds are capable of enhancing the activity of serum cholinesterase under some experimental conditions.

M. (1958), Lancet, 2, 267. BRETTAUER, R. , HANSEN, R. , and BERGREN, W. R. (1959). Proc. nut. Acad. Sci. ),45, 328. FOLCH-PI, J. (1955). I n Biochemistry of Developing Nervous System, p. 125, ed. Waelsch, H. New York: Academic Press. , and NIKAIDO, 1%(1959). ),in press. , and NEUFELD,E. (1957). -4bstr. Proc. Biol. , Amer. ckem. ,September, 27 C. HOLZEL, A. (1959). , Bern, 1958. HOLZEL, A,, and KOMROWER, G. &I. (1955). Arch. , 30, 155. ISSELBACHER, K. J. (1957). Science, 126, 652. ISSELBACHER, K.

N . Y . Acad. , 57,494. REES,H. (1955). Proc. roy. , 144,150. RENWICK, J. (1956). Ann. hum. , 21, 159. B. (1954). Ann. hum. , 19, 262. , and BIANCO,I. (1959). Ciba Found. Symp. Medical Biology and Etruscan Origins, p. 205. London: Churchill. SLATIS,H. , and REIS,R. H. (1957). Actu genet. ( B a d ) , 7, 53. STERN,C. (1943). Genetics, 28, 441. TJIO,J. , and PUCK,T. T. Proc. Nut. Acad. Sci. ),44, 1229. WRIGHT, S. (1931). Genetics, 16, 97. DISCUSSION Smithies :Prof. Penrose, you mentioned the search for incomplete recessivity.

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Biochemistry of human genetics by Cecelia M O'Connor; G E W Wolstenholme; International Union of Biological Sciences

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